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Scientific curiosity and passion have driven my academic career and enabled me to become an expert in the physico-chemical analysis of many different DNA secondary structures, such as duplexes, triplexes and G-quadruplexes. My work on highly-specific flexible intercalating units embedded into DNA led to the discovery of a novel class of molecules (twisted intercalating nucleic acid, TINA) that enables formation of stable DNA triplexes or G-quadruplexes. This work has laid the foundation for the 1st Platform.
My interest in development of novel tools for chemists inspired by Nature is behind the research on DNA-based chiral catalysis (Platform 2), while my research activity in the field of assembly of organic chromophores on the DNA scaffold is behind the project on DNA-based low-energy photon upconverters (Platform 3).
My knowledge in the functionalisation and manipulation of DNA on the pre- and post-synthetic level is pivotal for the success of these projects.