Cam Hoang

Doctor of Philosophy, (Anat/Physiology)
Study Completed: 2010
College of Sciences

Citation

Thesis Title
Mucin changes associated with abomasal parasitism in sheep

Mucins are the highly glycosylated molecules in mucus, that play important roles in prevention of infection by microorganisms and are also used by the pathogens to locate and invade their target tissues and as a source of nutrient. The sugars in mucins collected from the stomach and duodenum were analysed chemically and in tissue sections. Changes seen in the monosaccharide composition of sheep stomach and intestinal mucins during parasitism with either Haemonchus contortus or Teladorsagia (Ostertagia) circumcincta were similar to those in parasitised rats. An interesting observation was that changes in mucins were similar at all ages in the duodenum, but not in the stomach where the worms were located.  This suggests that the host immune response affects organs other than where there are parasites.  This may be useful in identifying susceptible or resistant sheep for genetic selection from changes in mucins in mucus in the nose or saliva

Supervisors
Professor Heather Simpson
Professor Bill Williams

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