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Associate Professor Vyacheslav Filichev staff profile picture

Contact details +64 (06) 356 9099  ext. 84659

Associate Professor Vyacheslav Filichev PhD, MSc

Associate Professor

School of Fundamental Sciences

Scientific curiosity and passion have driven my academic career and enabled me to become an expert in the physico-chemical analysis of many different DNA secondary structures, such as duplexes, triplexes and G-quadruplexes. My work on highly-specific flexible intercalating units embedded into DNA led to the discovery of a novel class of molecules (twisted intercalating nucleic acid, TINA) that enables formation of stable DNA triplexes or G-quadruplexes. This work has laid the foundation for the 1st Platform.

My interest in development of novel tools for chemists inspired by Nature is behind the research on DNA-based chiral catalysis (Platform 2), while my research activity in the field of assembly of organic chromophores on the DNA scaffold is behind the project on DNA-based low-energy photon upconverters (Platform 3).

My knowledge in the functionalisation and manipulation of DNA on the pre- and post-synthetic level is pivotal for the success of these projects.


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Professional

Qualifications

  • Doctor of Philosophy - St Petersburg State Technological Institute (2001)
  • Master of Science - St Petersburg State Technological Institute (1999)

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 5 12

Research Outputs

Consultancy and Languages

Languages

  • Danish
    Spoken ability: Average
    Written ability: Average
  • Russian
    Spoken ability: Excellent
    Written ability: Excellent

Teaching and Supervision

Courses Coordinated

Summary of Doctoral Supervision

Position Current Completed
Supervisor 4 0
Co-supervisor 2 0

Current Doctoral Supervision

Supervisor of:

  • Bruce Chilton - Doctor of Philosophy
    Development of modified DNA duplexes containing kinetically trapped G-quadruplexes
  • Harikrishnan Mohana Kurup Harikrishnan M - Doctor of Philosophy
    Reducing the mutational load in cancers: RNA-based inhibitors of APOBEC3 proteins
  • Yongdong Su - Doctor of Philosophy
    Portable assay for the detection of pathogenic DNA
  • Fareeda Barzak - Doctor of Philosophy
    Stopping cancer evolution: towards understanding of APOBEC3B-DNA interactions

Co-supervisor of:

  • Ruby Roach - Doctor of Philosophy
    Untangling protein- G-quadruplex interactions in heterochromatin formation

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