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I'm a cellular and molecular biologist whose research interests are focussed on chromatin biology and its dysfunction during tumorigenesis. Present research within my laboratory investigates the functional organisation of the genome within the nucleus, specifically the role of Heterochromatin Protein 1α, guanine quadruplex (G4) assemblies and histone H1 in mediating the partitioning of chromatin into domains of highly compacted heterochromatin . Also under investigation in the laboratory, is how the alter organisation of heterochromatin organisation, observed during tumorigensis, alters nuclear integrity thus contributing to the malignant phenotype.
Health and Well-being
Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000):
Cancer Cell Biology (111201):
Cell and Nuclear Division (060402): Epigenetics (incl. Genome Methylation and Epigenomics) (060404): Genetics (060400):
Medical And Health Sciences (110000): Oncology and Carcinogenesis (111200)
Project Title: Targeting HP1 regulated pathways to suppress breast cell invasion
Date Range: 2016 - 2018
Funding Body: Health Research Council of New Zealand